Neural Regulation Of Endocrine And Autonomic Stress Responses PdfBy Suchimorea In and pdf 20.01.2021 at 19:27 5 min read
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- Neuroendocrine Regulation of Stress Response in Clinical Models
- Neural regulation of endocrine and autonomic stress responses
- Neural Regulation of the Stress Response: The Many Faces of Feedback
- Stress (biology)
Neuroendocrine Regulation of Stress Response in Clinical Models
A stressful situation — whether something environmental, such as a looming work deadline, or psychological, such as persistent worry about losing a job — can trigger a cascade of stress hormones that produce well-orchestrated physiological changes. A stressful incident can make the heart pound and breathing quicken. Muscles tense and beads of sweat appear. This combination of reactions to stress is also known as the "fight-or-flight" response because it evolved as a survival mechanism, enabling people and other mammals to react quickly to life-threatening situations. The carefully orchestrated yet near-instantaneous sequence of hormonal changes and physiological responses helps someone to fight the threat off or flee to safety. Unfortunately, the body can also overreact to stressors that are not life-threatening, such as traffic jams, work pressure, and family difficulties.
Stress , either physiological , biological , or psychological is an organism's response to a stressor such as an environmental condition. Stimuli that alter an organism's environment are responded to by multiple systems in the body. The sympathoadrenal medullary SAM axis may activate the fight-or-flight response through the sympathetic nervous system , which dedicates energy to more relevant bodily systems to acute adaptation to stress, while the parasympathetic nervous system returns the body to homeostasis. The second major physiological stress-response center, the HPA axis, regulates the release of cortisol , which influences many bodily functions such as metabolic, psychological and immunological functions. The SAM and HPA axes are regulated by several brain regions, including the limbic system , prefrontal cortex , amygdala , hypothalamus , and stria terminalis.
Neural regulation of endocrine and autonomic stress responses
The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids GCs are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and restore homeostasis after the immediate threat has subsided. Release of GCs is mediated by the hypothalamo—pituitary—adrenocortical HPA axis, driven by a neural signal originating in the paraventricular nucleus PVN. Stress levels of GCs bind to glucocorticoid receptors GRs in multiple body compartments, including brain, and consequently have wide-reaching actions. For this reason, GCs serve a vital function in feedback inhibition of their own secretion. Fast, non-genomic feedback inhibition of the HPA axis is mediated at least in part by GC signaling in the PVN, acting by a cannabinoid-dependent mechanism to rapidly reduce both neural activity and GC release.
Neural Regulation of the Stress Response: The Many Faces of Feedback
The past decades have witnessed an increasing societal awareness of child maltreatment, such as abuse and neglect, which is now considered a public health problem of epidemic dimensions. Compelling evidence suggests that childhood trauma is a major risk factor for the development of mood and anxiety disorders as well as certain medical diseases, including heart disease and disorders such as chronic fatigue and pain syndromes. The precise mechanism that mediates the effects of early adversity on later stress vulnerability and disease risk has been the subject of intense inquiry in neuroscience research.
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Important User Information: Remote access to EBSCO's databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use. However, remote access to EBSCO's databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Source: Nature Reviews Neuroscience. Jun, Vol. Author s : Ulrich-Lai, Yvonne M. Abstract: The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges.
Ulrich-Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci July ; Nature.
Neuroendocrinology and Behavior. A stress response is an evolutionary heritage of ability to anticipate, identify and effectively respond to danger. After millions of years of evolution, perception of variety of stressors mobilizes neurologic, neuroendocrine, endocrine, immunologic and metabolic systems to maintain an ability to survive and propagate gens natural selection. Additionally, in humans these mechanisms involve complex and interrelated mental, emotional, behavioral and social processes. Behavioral adaptation is aimed on modulation of neural pathways that help to cope with stressful situations. These e.
By Saul McLeod , published
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