Technetium Chemistry And Radiopharmaceutical Applications Pdf

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technetium chemistry and radiopharmaceutical applications pdf

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Even today, technetiumm is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetiumm make it suitable as an available radionuclide in many centers.


Technetium is a chemical element with the symbol Tc and atomic number It is the lightest element whose isotopes are all radioactive , none of which are stable other than the fully ionized state of 97 Tc. Naturally occurring technetium is a spontaneous fission product in uranium ore and thorium ore, the most common source, or the product of neutron capture in molybdenum ores. The silvery gray, crystalline transition metal lies between manganese and rhenium in group 7 of the periodic table , and its chemical properties are intermediate between those of both adjacent elements. The most common naturally occurring isotope is 99 Tc, in traces only. Many of technetium's properties had been predicted by Dmitri Mendeleev before it was discovered. Mendeleev noted a gap in his periodic table and gave the undiscovered element the provisional name ekamanganese Em.

Technetium and rhenium - coordination chemistry and nuclear medical applications. Coordination compounds of the radioactive element technetium are well established in diagnostic nuclear medicine, and various complexes of the g -emitting nuclide 99m Tc are routinely used for organ imaging. Modern trends in the radiopharmaceutical chemistry of technetium focus on the 'labeling' of biologically active molecules such as peptides, steroids or other receptor-seeking units. This requires more knowledge about the coordination chemistry of the artificial transition metal, particularly with regard to stable or kinetically inert coordination spheres, which allow couplings to biomolecules following a bioconjugate approach. Keywords: technetium, rhenium, coordination chemistry, nuclear medicine, bioconjugates. As members of group 7 of the Periodic Table, the elements with the atomic numbers 43 technetium and 75 rhenium possess a rich coordination chemistry. This covers eight different oxidation states and various ligand systems reaching from almost pure electron donors, such as oxo or imido ligands to systems with pronounced back-donating properties such as carbonyls or isocyanides.

JavaScript is disabled for your browser. Some features of this site may not work without it. Search MOspace. This Collection. Format Thesis. This makes them attractive candidates for incorporation into pharmaceuticals.

Technetium Complexes and Radiopharmaceuticals with Scorpionate Ligands

Not a MyNAP member yet? Register for a free account to start saving and receiving special member only perks. The content of this chapter, particularly the sections delineating needs and impediments, is derived largely from discussions with and presentations from chemists and other researchers working in the nuclear medicine field. The impact of the shortage of radionuclides was discussed in detail in Chapter 5. Background 6. Significant Discoveries 6. Current State of the Field and Emerging Priorities 6.

Technetium: Chemistry and Radiopharmaceutical Applications provides a comprehensive survey of the present status of Technetium chemistry and its radiopharmaceutical applications. PDF · Request permissions.

Radiopharmaceutical Chemistry

In the last 15 years, computational quantum chemistry has become an invaluable tool that supports the interpretation of experimental measurements of a broad range of molecular properties of Tc and Re compounds. Among the contemporary computational techniques, density functional theory is the most extended one. This review describes recent computational investigations that illustrate best the promise of quantum chemical calculation in a number of areas of Tc and Re chemistry, such as geometry, stability of complexes, molecular spectroscopic properties and electronic structures and bonding characters. General trends and the prospects for future applications are also discussed. If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using Copyright Clearance Center.

The purpose of this short review is to provide an illustration of the most general and relevant results in this field, however without being concerned with the details of the analytical features of the various compounds. Thus, emphasis will be given to the description of the general features of technetium complexes with scorpionate ligands including coordination modes, structural properties and an elementary bonding description.

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